Vasoactive intestinal peptide test

定义

Vasoactive intestinal peptide (VIP) is a test that measures the amount of VIP in the blood.

选择的名字

VIPoma - vasoactive intestinal polypeptide test

How the Test is Performed

A blood sample is needed.

How to Prepare for the Test

You should not eat or drink anything for 4 hours before the test.

How the Test Will Feel

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.

Why the Test is Performed

This test is used to measure the VIP level in the blood. A very high level is usually caused by a VIPoma. This is an extremely rare tumor that releases VIP.

VIP is a substance found in cells throughout the body. The highest levels are normally found in cells in the nervous system and 肠道. VIP has many functions, including relaxing certain muscles, triggering the release of hormones from the pancreas, 肠道, 和下丘脑, and increasing the amount of water and electrolytes secreted from the pancreas and 肠道.

VIPomas produce and release VIP into the blood. This blood test checks the amount of VIP in the blood to see if a person has a VIPoma.

Other blood tests including serum potassium may be done at the same time as the VIP test.

正常的结果

Normal values should be less than 70 pg/mL (20.7 pmol / L).

People with VIP-secreting tumors usually have values 3 to 10 times above the normal range.

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.

What Abnormal Results Mean

A higher-than-normal level, along with symptoms of watery diarrhea and flushing, may be a sign of a VIPoma.

Moderately elevated levels can be caused by other diseases of the 肠道, including irritation of the 肠道 lining and decreased blood flow in the 肠道.

风险

There is little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight but may include:

• 大出血
• Fainting or feeling lightheaded
• Multiple punctures to locate veins
• Hematoma (blood accumulating under the skin)
• Infection (a slight risk any time the skin is broken)

参考文献

奥伯格K. Neuroendocrine tumors and related disorders. In: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14日艾德. Philadelphia, PA: Elsevier; 2020:chap 45.

Siddiqi HA, Rabinowitz S, Axiotis CA . Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24日艾德. Philadelphia, PA: Elsevier; 2022:chap 23.